This workshop will introduce essential elements of Distributed Drug Discovery. D3 labs enable student engagement in the fundamental research process of observation, hypothesis/prediction and experimentation utilizing computational, synthetic and biological testing lab modules. You will consider known drug leads for the possible treatment of Leishmaniasis, form hypotheses, and computationally select new analogs with potential drug activity. You will then carry out the synthetic steps shown to make these six new compounds using simple, robust, reproducible procedures, and inexpensive equipment. The polymer-bound products will be cleaved and analyzed off-site and the results from your six N-acylated unnatural amino acids will be provided following the workshop. You will also conduct a biological assay to screen potential antibacterials made in a student lab at IUPUI.